Analgesic efficacy of local anaesthetic wound administration in knee arthroplasty: volume vs concentration

Analgesic efficacy of the intra-articular administration of S(+)- ketamine in patients undergoing total knee arthroplasty.

BACKGROUND AND OBJECTIVES Total knee arthroplasty (TKA) is associated with significant postoperative pain. Many intra-articular (IA) agents have been used for postoperative analgesia with inconsistent outcomes. Ketamine's enantiomer S(+), S(+)- ketamine, was recently introduced commercially, with higher analgesic potency and less side effects than the racemic form. An experimental prospective r...

Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: a systematic review.

In recent years, there has been an increasing interest in local infiltration analgesia (LIA) as a technique to control postoperative pain. We conducted a systematic review of randomized clinical trials investigating LIA for total knee arthroplasty (TKA) and total hip arthroplasty (THA) to evaluate the analgesic efficacy of LIA for early postoperative pain treatment. In addition, the analgesic e...

Efficacy of Intra-articular Local Anesthetics in Total Knee Arthroplasty.

Pain management after total knee arthroplasty (TKA) remains among the most important challenges for patients with TKA. Intra-articular local anesthetic has been shown to reduce postoperative pain following TKA. However, studies report conflicting results. This meta-analysis evaluated the efficacy and safety of single-dose intra-articular local anesthetics for pain control after TKA. Databases (...

High-volume Local Infiltration Analgesia in Hip and Knee Arthroplasty

Analgesic efficacy of the intra-articular administration of high doses of morphine in patients undergoing total knee arthroplasty.

BACKGROUND AND OBJECTIVES Although the efficacy of intraarticular (IA) morphine is still controversial, it has been shown that higher doses promote better results and consequently decrease postoperative analgesic consumption, characterizing a dose-dependent peripheral action. A controlled, randomized, double-blind study was undertaken to evaluate the efficacy of the intra-articular administrati...